OPENRATIO
OpenRatio mark
OPEN
RATIO

Clearer neurological data, wherever care happens.

Open standards and measurement tools that help clinicians and researchers compare, track and understand neurological signals.

Why OpenRatio

Neurology runs on ratios. The rhythm of brain activity, the flow of blood, the steadiness of a hand: each is a measure clinicians read to make decisions.

The ratio that matters most is out of balance. Billions of people live with neurological conditions, yet the specialists, tools and data they depend on are concentrated in a few places. Across stroke, epilepsy, essential tremor and Parkinson's disease, the same three problems recur: diagnosis comes late, specialists are overstretched, and data sits in systems that cannot talk to each other.

OpenRatio exists to restore that balance, and the name is the method.

Open

Shared standards, shared tools and transparent AI that connect regions, hospitals and researchers.

Ratio

Complex neurological data turned into clear, consistent measures that help clinicians reach better-informed decisions sooner, wherever they work.

The evidence

Ten things the numbers tell us.

Six about health, four about the economy. Every figure is sourced.

Health

01 · Scale

The leading cause of ill health and disability worldwide.

3.4Bpeople, 43% of the world, lived with a neurological condition in 2021: the leading cause of ill health and disability.Lancet Neurology, 2024 ↗
11M+deaths a year from neurological disorders.WHO Global Status Report on Neurology, 2025 ↗
+59%rise in the number of people with neurological conditions since 1990.Lancet Neurology, 2024 ↗
11.9Mnew strokes a year; 93.8 million people live after a stroke.World Stroke Organization, 2025 ↗

02 · Inequity

It falls hardest where care is thinnest.

80%+of neurological deaths and health loss occur in low- and middle-income countries.Lancet Neurology, 2024 ↗
80×+fewer neurologists per 100,000 people in low-income countries than in high-income countries.WHO Global Status Report on Neurology, 2025 ↗
89%of the disability from stroke falls on low- and lower-middle-income countries.World Stroke Organization, 2025 ↗
50Mpeople live with epilepsy, nearly 80% of them in low- and middle-income countries.WHO, 2024 ↗

03 · Women

It weighs most heavily on women, who are least represented in the research.

2×Women are twice as likely as men to live with multiple sclerosis.MS International Federation, Atlas of MS, 2020 ↗
2 in 3Almost two in three Americans living with Alzheimer’s disease are women.Alzheimer’s Association, 2026 ↗
No. 3Migraine, more common in women, is the third-largest neurological cause of ill health and disability worldwide, after stroke and newborn brain injury.Lancet Neurology, 2024 ↗
37%of participants in stroke trials were women, though women make up 48% of people with stroke.Neurology, 2021 ↗

04 · Readiness

The systems to respond are largely missing.

32%of countries have a national policy for neurological disorders; 18% fund one.WHO Global Status Report on Neurology, 2025 ↗
25%of countries include neurological disorders in their universal health coverage benefits.WHO Global Status Report on Neurology, 2025 ↗
3 in 4people with epilepsy in low-income countries do not get the treatment they need.WHO, 2024 ↗

05 · Opportunity

Much of it can be changed.

Up to 70%of people with epilepsy could live seizure-free if properly diagnosed and treated.WHO, 2024 ↗
84%of the global stroke burden is linked to modifiable risk factors such as high blood pressure, air pollution and smoking.World Stroke Organization, 2025 ↗

06 · Trajectory

It is growing fast, as populations age.

25.2Mpeople projected to live with Parkinson's disease by 2050, up 112% from 2021.The BMJ, 2025 ↗
57Mpeople live with dementia, with nearly 10 million new cases a year.WHO, 2026 ↗
2.9Mpeople live with multiple sclerosis; someone is diagnosed every five minutes.MS International Federation, 2023 ↗
5.8%of people aged 65 and over live with essential tremor, often called the most common movement disorder in adults.Louis and McCreary, 2021 ↗

Economy

07 · Counted

What health systems pay is already vast.

$890B+a year for stroke alone: 0.66% of the entire world economy, from one condition, and projected to nearly double by 2050.World Stroke Organization, 2025 ↗
$1.3Ta year: the global cost of dementia in 2019, about half of it informal care.WHO, 2026 ↗
$119Ba year: the global cost of epilepsy, in 2019 dollars.Epilepsia, 2022 ↗
$85.4Ba year: the economic burden of multiple sclerosis in the United States alone.Neurology, 2022 ↗

08 · Uncounted

Most of the cost never reaches a hospital bill.

63%of the cost of brain disorders in Europe falls outside health care: in social and family care, and in lost work.European Brain Council, 2011 ↗
5 hrsof unpaid care a day, on average, for each person living with dementia.WHO, 2026 ↗
40Mfull-time workers’ worth of unpaid dementia care worldwide in 2015, rising to 65 million by 2030.Alzheimer’s Disease International, 2018 ↗
$446Bvalue of 19 billion hours of unpaid dementia care in the United States in 2025 alone.Alzheimer's Association, 2026 ↗

09 · Carers

Women carry much of that hidden cost, and closing the gap pays.

70%of unpaid dementia care hours worldwide are provided by women.WHO, 2026 ↗
25%more time spent in poor health by women than by men, over a lifetime.McKinsey Health Institute and World Economic Forum, 2024 ↗
56%of women's health burden comes from conditions that are more common in women or affect them differently.McKinsey Health Institute and World Economic Forum, 2024 ↗
Up to $1Ta year could be added to the global economy by 2040 if the women’s health gap is closed.McKinsey Health Institute and World Economic Forum, 2024 ↗

10 · Direction

The bill is compounding.

$6.2Tin global GDP at stake by 2050: the gain if proven ways to protect brain health were scaled up, with brain conditions now nearly a quarter of the world’s disease burden.McKinsey Health Institute and World Economic Forum, 2026 ↗
$1.7Ta year by 2030: projected global cost of dementia, before any rise in the cost of care.World Health Organization, 2021 ↗
€798Ba year: cost of brain disorders across Europe, measured in 2010; 40% of it is lost productivity.European Brain Council, 2011 ↗
$82Ba year: the US cost of Parkinson’s in 2024, a level not expected until 2037.Parkinson’s Foundation, 2024 ↗

Focus areas

One shared data foundation, many conditions.

NeuroLexAn open framework that helps EEG, wearable, imaging and clinical data work together across systems, building on established standards such as BIDS, SCORE and OMOP.In development · open specification planned
Movement measuresTools that quantify tremor and movement from everyday sensors, starting with essential tremor and extending to related movement conditions.Research and validation
Brain activity and episodic eventsTools that organize EEG recordings and event records so clinicians can review them more efficiently, especially where specialists are scarce.Exploratory research · partner-led

NeuroLex

Neurological conditions differ clinically, but their data is built from a small set of shared parts. NeuroLex standardizes each part once, so every condition that uses it inherits the work. It builds on established standards, including BIDS, HED, SCORE, EDF+, OMOP and FHIR, and makes them work together in practice, including with legacy and low-resource data.

Planned scope

DataConditions it serves
Motion and inertial signalsEssential tremor, Parkinson's, MS, stroke recovery
Electrophysiology (EEG, EMG)Epilepsy, sleep, dementia, tremor
Episodic eventsEpilepsy, Parkinson's, MS, migraine, syncope
Rater scales and patient-reported outcomesAll of the above
Medication and dosing timelinesParkinson's, epilepsy, essential tremor
Speech and voiceParkinson's, ALS, MS, dementia
Imaging reportsStroke, MS, dementia

Research

Assistive designs for people living with tremor.

Alongside the data work, we study simple, low-cost aids for daily tasks. Each is an engineering concept at an early research stage, documented with calculations, CAD models, drawings and a priced bill of materials. They are not medical devices and are not available for use.

StillBand concept renderStillBandConcept · TRL 3A battery-free bracelet concept that uses a small tuned mass damper to study whether wrist and forearm tremor can be damped passively, with no electronics or charging.
SteadyKit concept renderSteadyKitConcept · TRL 3Four simple, non-electronic aids for meals, writing and dressing, designed to adapt objects a person already owns and to be made by volunteers.
SteadySleeve concept renderSteadySleeveConcept · TRL 3A fingerless forearm sleeve concept for studying compression, light weighting and vibration separately, with an optional motion sensor to record tremor for review.

Principles

How we work

With clinicians

  • Tools that work with neurologists, organizing and quantifying data so they can spend more time with patients.
  • Refined with real-world input from neurologists, patients and technologists.
  • Tested rigorously with clinical partners, because consistency matters.

One language for data

  • NeuroLex lets data from different systems work together, so results stay comparable across sites and regions.
  • Scans, sensors and patient histories brought together into one consistent record.

Built for anywhere

  • Low-cost devices, offline use and simple interfaces, so tools can work in any clinic.
  • Stable on a high-connectivity urban network or offline in a rural setting.
  • Extending specialist reach where it is scarcest, and accelerating research where systems are advanced.

Responsible by design

  • Rigorous testing, bias checks and safeguards against misuse at every release.
  • Research tools and standards shared openly; models released only after appropriate review.
  • No claims about time saved, reach or outcomes until documented studies with partners support them.

Who we are

We are builders, technologists, product designers, operators, patients, doctors and scientists united by a shared belief:

Neurological care should be timely, accessible and data-driven, no matter where you live.

Our diverse perspectives give us the empathy to see the patient's journey, the skill to design useful tools, and the determination to bring them into everyday clinical practice.

Founding team

Amish Chadha
Amish ChadhaFounder

Amish is an engineering technologist who has spent his career getting disconnected systems to work as one, in factories, power networks and critical infrastructure. He has led technology teams at Fortune 500 and global engineering companies and is a recognized speaker on emerging technology. He is a leader at Helpful Engineering, a global open engineering nonprofit, serves on the national board of the Association for Manufacturing Excellence, sits on the IEEE standards working group, and takes on technical projects with industry. He has watched family and friends live with neurological conditions, and noticed something he could not unsee: a factory often knows more about the health of its machines than a clinic can know about a patient's tremor between visits. OpenRatio is his attempt to close that gap.

Dr. Geeti Chadha
Dr. Geeti ChadhaCo-founder and Clinical Lead

Dr. Chadha is a neurologist and clinical neurophysiologist who spent 46 years in public health service with the Ministry of Health in Kuwait, with particular depth in stroke and multiple sclerosis. Her research and work on stroke earned her a lifetime service award from the Ministry. During her career, MS in Kuwait rose from 9.5 people per 100,000 to about 78, more than double today's global average and the Eastern Mediterranean rate, and new cases nearly quadrupled between the late 1980s and the late 1990s. Stroke carried an equally unusual load: in one Kuwait study, 69% of people with ischemic stroke also had diabetes, the highest share reported in the Middle East. She cared for people with stroke and MS at national scale as both conditions climbed. That experience gives OpenRatio clinical insight that carries across the Gulf and the wider Middle East and North Africa: which measures matter, and how each tool fits into a neurologist's day.

We are a small team and growing. Join us

Join us

We are looking for:

connect@openratio.org